研究目的
建立一种基于光学相干断层扫描（OCT）的外周肺动脉成像方法。
研究成果
改进的肺动脉成像方法（IPI）用于外周肺动脉光学相干断层扫描安全有效，与常规方法相比能获得更高比例的优质图像，其可控并发症通过氧疗即可缓解。
研究不足
该研究样本量较?。ń霭嗣颊撸?，可能影响结果的普适性。研究在单中心开展，其发现需通过更大规模的多中心研究进一步验证。
1：实验设计与方法选择：
本研究比较了两种光学相干断层成像（OCT）方法——常规OCT成像（COI）和改进型肺动脉成像（IPI）。IPI采用造影剂作为球囊充盈指示剂并提高冲洗速度。
2：样本选择与数据来源：
2009年9月至2010年9月期间，从广州医科大学第一附属医院和广州呼吸疾病研究所招募8例外周肺动脉病变患者。
3：实验设备与材料清单：
包括血管造影仪（INNO-VA2000，GE）、OCT成像仪（M2系列，LightLab Imaging公司）、封堵球囊导管（HeliosTM，LightLab Imaging公司）、低压球囊加压泵（Indeflator LID-1，GoodTec）、导丝、导管、造影剂（威视派克，GE）、肝素钠、盐酸利多卡因、无菌生理盐水及乳酸林格氏液。
4：实验流程与操作步骤：
COI组充盈压力为0.3-0.5 atm，冲洗速度0.3-0.5 mL/s；IPI组在X线监测下逐步增加充盈压力并配合造影剂使用，冲洗速度提升至1.0 mL/s。共对33个血管段进行OCT成像。
5：3-5 atm，冲洗速度3-5 mL/s；IPI组在X线监测下逐步增加充盈压力并配合造影剂使用，冲洗速度提升至0 mL/s。共对33个血管段进行OCT成像。 数据分析方法：
5. 数据分析方法：采用SPSS 12.0软件进行统计分析，百分比数据行χ2检验，均值数据行t检验，以P<0.05为显著性差异标准。
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INNO-VA2000
INNO-VA2000
GE
Fully digital X-ray vascular angiography instrument used for imaging and monitoring during the procedure.
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OCT imager M2 series
M2 series
LightLab Imaging Inc.
Intravascular imaging system for optical coherence tomography, used to produce high-resolution images of blood vessels.
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HeliosTM OBC
HeliosTM
LightLab Imaging Inc.
Occlusion balloon catheter used to block proximal blood flow and allow flushing with replacement fluid during OCT imaging.
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Indeflator LID-1
LID-1
GoodTec
Low-pressure balloon pressurization pump used to inflate the occlusion balloon with controlled pressure.
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ImageWireTM
ImageWireTM
LightLab Imaging Inc.
OCT imaging guidewire with a radiopaque marker, used to advance through vessels for imaging.
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Arterial sheath
5 or 6 Fr
Terumo
Used for vascular access during the angiography procedure.
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Guiding catheter
Multi-purpose imaging tube (MP)
Cordis Corporation
Used to guide catheters and wires during the imaging procedure.
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Pigtail angiographic catheter
MP
Cordis Corporation
Used for angiography to visualize blood vessels.
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Long guidewire
Amplatz
USA
Guidewire with hydrophilic coating, used for navigating through vessels.
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Soft-top guidewire
PILOT series/CROSS series/BMW ATW
USA
Guidewire used for precise navigation in vessels.
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Visipaque
Iodixanol injection
GE
Contrast agent used during imaging to enhance visibility under X-ray.
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Heparin sodium
Tianjin Biochem Pharmaceutical Co. Ltd.
Anticoagulant used for systemic anticoagulation during the procedure.
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Lidocaine hydrochloride
2%
Treechem BioTech Co. Ltd.
Local anesthetic used for anesthesia at the procedure site.
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Sterile saline
Chongqing Daxin Pharmaceutical Co. Ltd.
Used to clean catheters and guidewires.
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Lactated Ringer's solution
Qingzhou Yao Wang Pharmaceutical Co. Ltd.
Replacement fluid used for flushing the vessel lumen during OCT imaging.
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