研究目的
Investigating the therapeutic effects of photoactive nanocarriers on controlled delivery of active payloads using light as an external stimulus.
研究成果
Photoactive nanocarriers based on synergistic mechanisms have demonstrated enhanced therapeutic efficacy. Light as an external stimulus has enabled high spatiotemporal precision, minimal invasiveness, and on-demand sequential delivery of payloads. Despite the promise demonstrated in preliminary studies, there are still key challenges to be addressed before the technology may be translated into clinical settings.
研究不足
The limited penetration depth of UV and visible light hinders their clinical applications. The long-term biosafety and scaled-up preparation of nanocarriers are major technical hurdles for clinical applications.
1：Experimental Design and Method Selection:
The paper discusses the design and fabrication of photoactive nanoplatforms based on photochemical reactions, photothermal effects, and photosensitization mechanisms.
2：Sample Selection and Data Sources:
The study focuses on the delivery of various payloads ranging from small molecule drugs to therapeutic macromolecules using photoactive nanocarriers.
3：List of Experimental Equipment and Materials:
Includes noble metal nanomaterials, nonmetallic nanomaterials, and organic-inorganic hybrid photosensitizers.
4：Experimental Procedures and Operational Workflow:
Describes the use of light irradiation to trigger payload release from nanocarriers.
5：Data Analysis Methods:
The effectiveness of the delivery systems is evaluated through in vitro and in vivo studies.
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