研究目的
To develop an inorganic semiconductor heterojunction photocatalyst of Bi2S3@Ag3PO4 on a Ti implant that effectively eliminates biofilm within a short time using 808 nm NIR light.
研究成果
The Bi2S3@Ag3PO4/Ti hybrid coating exhibits superior bactericidal and antibiofilm efficacy under NIR light irradiation, along with good biocompatibility, making it a promising strategy for the surface modification of bone implant materials to prevent bacterial infections.
研究不足
The study focuses on the short-term effects of the hybrid coating under NIR light irradiation. Long-term stability and biocompatibility in vivo, as well as the potential for bacterial resistance, require further investigation.
1：Experimental Design and Method Selection:
The study involves the preparation of Bi2S3 nanorod arrays on titanium implants through hydrothermal methods and loading Ag3PO4 nanoparticles on Bi2S3 NR arrays using a stepwise electrostatic adsorption strategy.
2：Sample Selection and Data Sources:
Titanium implants were used as the substrate for the hybrid coating.
3：List of Experimental Equipment and Materials:
Hydrothermal synthesis setup, electrostatic adsorption equipment, NIR light source (808 nm).
4：Experimental Procedures and Operational Workflow:
Preparation of Bi2S3 NR arrays, loading of Ag3PO4 NPs, characterization of the hybrid coating, evaluation of photocatalytic and photothermal effects, in vitro and in vivo antibacterial and antibiofilm assays.
5：Data Analysis Methods:
Photocatalytic performance was evaluated by measuring ROS production, photothermal effects were assessed by temperature changes, and antibacterial efficacy was quantified by bacterial survival rates.
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