研究目的
To develop a highly stretchable kirigami structure with integrated LED chips and electrodes for optogenetic experiments on perfused hearts, aiming to reduce the side effects of traditional electrical stimulation methods.
研究成果
The study successfully demonstrates a highly stretchable kirigami device for optogenetic stimulation in cardiac tissue, with a 100% yield in LED functionality tests. This approach is expected to mitigate the severe side effects associated with traditional electrical defibrillation methods.
研究不足
The manual application of encapsulation materials may lead to uneven spreading, potentially covering microelectrodes. Future work includes using photolithographically defined confinement structures to address this issue.
1：Experimental Design and Method Selection:
The study employs a kirigami structure made from polyimide membranes for high stretchability, integrating LED chips and microelectrodes for optogenetic stimulation and ECG measurements.
2：Sample Selection and Data Sources:
The device is designed for use on perfused mouse hearts.
3：List of Experimental Equipment and Materials:
Includes polyimide membranes, LED chips (TR2227 by CREE), platinum and gold for electrodes and interconnections, and encapsulation materials (EpoTek 301-2, Cytop 809M, Elastosil RT604).
4：4). Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Fabrication involves spin-coating polyimide layers, metallization, LED chip bonding, and encapsulation. The device is then tested for functionality and stretchability.
5：Data Analysis Methods:
Optical, electrical, and mechanical characterization of the kirigami devices, including long-term stability and durability tests.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
