研究目的
To determine whether photobiomodulation (PBM) might be effective for chemotherapy-induced palmo-plantar erythrodyesthesia (PPED), as it is for mucositis or radio dermatitis.
研究成果
We concluded that PBM represents a potentially useful approach for the management of PPED but that future studies should concentrate on larger number of patients, with more uniform clinical characteristics, and the use of higher illumination energy. Cooperative multicenter studies should be contemplated.
研究不足
Firstly, it has been conducted, as a preliminary investigation, in a small series of patients, who received several types of cancer therapy, for various neoplasms, making our study population quite heterogeneous. Second, our study has been made with an energy of 2 J/cm2, using red and infrared illumination. The dose and the duration of the illumination were inspired by the schedule that proved to be successful in the management of oral mucositis. Nonetheless, it has been recently suggested that the needed energy might be higher for radiodermatitis; at least 4 J/cm2.
1：Experimental Design and Method Selection:
A preliminary controlled study to evaluate PBM as a treatment of PPED induced by various anti-cancer treatments. Patients were allocated to PBM or sham irradiation and were blindly assessed after 2 weeks.
2：Sample Selection and Data Sources:
Patients at the Institut Jules Bordet, who presented with a bilateral grade 1–3 PPED, associated with anti-cancer therapy, were eligible for the study after providing an informed consent.
3：List of Experimental Equipment and Materials:
The PBM treatment was given using a Mobile Thor Laser with a 69-diode type led probe (34 × 660 nm LED). The energy delivered was 2 J/cm2 with an intensity of 500 mU.
4：Experimental Procedures and Operational Workflow:
PBM or sham therapy was applied to the whole surface of the palms and soils, 3 times a week. Emollients could be used according the patient’s preferences. The patients were evaluated, by the blinded observer, after 2 weeks of therapy.
5：Data Analysis Methods:
We considered as a success of PBM, for both sides (treated or sham-irradiated), a non-progression of the lesions. The patients were asked to evaluate local pain using an analogic scale from 0 to 10 and record it weekly; at the same time, the patient expressed his/her overall satisfaction over the treatment, on a special form, weekly.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
