研究目的
Investigating the Rhodium(III)-catalyzed domino annulation of simple olefins with diazo oxindoles to synthesize spirooxindole pyrrolone products.
研究成果
The study successfully developed a RhIII-catalyzed annulation method for synthesizing spirooxindole pyrrolones, demonstrating its utility in late-stage drug diversification. The reaction proceeds through a unique sequence of C(cid:2)H activation, carbene insertion, Lossen rearrangement, and nucleophilic addition.
研究不足
The reaction conditions require optimization to suppress hydroxylation and improve yields. The scope of substrates is broad but may have limitations with certain functional groups.
1：Experimental Design and Method Selection:
The study utilized a Rhodium(III)-catalyzed domino annulation approach.
2：Sample Selection and Data Sources:
N-pivaloyloxy acrylamides and diazo oxindoles were used as substrates.
3：List of Experimental Equipment and Materials:
[RhCp*Cl2]2 was used as the catalyst, with MeCN as the solvent.
4：Experimental Procedures and Operational Workflow:
The reaction was conducted at various temperatures, with the addition of molecular sieves to remove H2O.
5：2O. Data Analysis Methods:
5. Data Analysis Methods: Yields were determined by 1H NMR spectroscopy using CH2Br2 as an internal standard.
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