研究目的
Investigating the Rhodium-catalysed [4 + 2] annulation of aromatic oximes with terminal alkenes for the synthesis of 3,4-dihydroisoquinolines.
研究成果
The Rh(III)-catalysed redox-neutral [4 + 2] annulation of aromatic oximes with terminal alkenes provides a practical method for the synthesis of 3,4-dihydroisoquinolines with excellent selectivity and functional group compatibility. This method represents a significant advancement in the field of C(cid:0) H functionalization.
研究不足
The reaction is limited to certain types of alkenes and requires specific conditions (e.g., argon atmosphere, specific temperature). Some alkenes, such as 1,1-diphenylethene and acrylates, were inert under the reaction conditions.
1：Experimental Design and Method Selection:
The reaction involves the use of [Cp*RhCl2]2 as a catalyst and K2HPO4 as a base in MeCN under argon atmosphere at 80 °C for 12 h.
2：Sample Selection and Data Sources:
Aromatic oximes and terminal alkenes were selected as substrates.
3：List of Experimental Equipment and Materials:
[Cp*RhCl2]2, K2HPO4, MeCN, and various aromatic oximes and terminal alkenes.
4：Experimental Procedures and Operational Workflow:
The substrates were mixed with the catalyst and base in MeCN and stirred under argon at 80 °C. The reaction was monitored by TLC and/or GC-MS.
5：Data Analysis Methods:
The products were purified by silica gel column chromatography and analyzed by NMR and mass spectrometry.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
