研究目的
To improve the sensitivity of optical fiber based LSPR sensor by developing a 3D nanostructure using ZnO nanowires and Au nanoparticles for highly sensitive plasmonic biosensing.
研究成果
The 3D FO-LSPR sensor with ZnO nanowires and AuNPs demonstrated significantly improved sensitivity and LOD for PSA detection compared to the 2D sensor, making it suitable for high sensitivity real-time label-free biosensing applications.
研究不足
The study mentions the increased coefficient of variation (CV) in the 3D FO-LSPR sensor due to the added fabrication process, which could affect reproducibility. Optimization of growth conditions of ZnO nanowires and immobilization conditions of Au nanoparticles is suggested for improvement.
1：Experimental Design and Method Selection:
The study involved the fabrication of FO-LSPR sensors with 3D nanostructures using ZnO nanowires and AuNPs. The sensors were designed to enhance sensitivity through an extended sensing area, light trapping effect by nanowires, and a simple optical system based on an optical fiber.
2：Sample Selection and Data Sources:
The sensors were tested with solutions of different refractive indices and various concentrations of prostate-specific antigen (PSA).
3：List of Experimental Equipment and Materials:
Equipment included a fiber-optic-based measurement set-up with a light source, detector, and optical fiber coupler, FE-SEM for imaging, and various chemicals for sensor fabrication.
4：Experimental Procedures and Operational Workflow:
The fabrication process involved growing ZnO nanowires on optical fibers and immobilizing AuNPs on the nanowires. The sensors were then tested for refractive index sensitivity and PSA detection.
5：Data Analysis Methods:
The sensitivity of the sensors was calculated based on the ratio of LSPR intensity change per unit change of the refractive index. The LODs for PSA detection were determined based on the standard deviations of the intensity differences and the slope of the fitting line.
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photodetector
PDA36A
Thorlabs
Used for detecting LSPR signals.
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optical fiber
FG105LCA
Thorlabs
Used as the substrate for the FO-LSPR sensor.
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FE-SEM
S-5200
Hitachi
Used for imaging the fabricated nanostructures.
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white light
LS-1
Ocean optics
Used as a light source for measuring spectra.
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hot plate
HSD180
MTOPS
Used for drying and annealing processes during sensor fabrication.
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oven
TH-ME-025
Jeio Tech
Used for the growth of ZnO nanowires.
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oxygen plasma
CUTE
Femto Science
Used for surface treatment of nanowires to generate hydroxyl groups.
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fusion splicer
A-80S
Walfront
Used for splicing the fabricated FO-LSPR sensor to the optical fiber coupler.
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spectrometer
SM200
Spectral Products
Used for detecting the LSPR spectra.
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laser source
Iflex-2000
Qioptiq
Used for observing LSPR intensities.
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