摘要： Y2SiO5: Ce (YSO) scintillation with characteristics of high light yield, fast decay time and high Compton scattering fraction shows good application potential for Compton imaging. In this study, we propose a three-dimensional (3-D) scintillator detector, which is segmented by the YSO monolithic rods and pixelated by sub-surface laser engraving (SSLE) in the depth direction. Two arrays of silicon photomultipliers are optically coupled to the YSO array at each end, in which the pixels are designed for a one-to-one match. By identifying the location number of array pixels and measuring depth-of-interaction (DOI) of pixelated scintillator rods, the interaction coordinates of gamma photon can be obtained accurately. After energy consistent calibration, the energy resolutions of the pixels in 3-D detector were evaluated. The imaging test results indicate that the detector has a capability to locate a 0.1 μSv/h Cs-137 gamma-ray source within 90 seconds in 4π field-of-view (FOV). The efficiency of the imaging events is 2.2 %. By using the maximum likelihood expectation maximization (MLEM) algorithm with 10 iterations, the full width at half maximum (FWHM) of the reconstructed hotspot decreases to less than 9.0 °. This configuration mainly simplifies the calculation of interaction coordinates compared to the center of gravity method. Moreover, the higher segment precision for DOI estimation are realized thanks to the SSLE technique. The 3-D scintillator detector achieves 4π Compton imaging with high detection efficiency and high localization accuracy.