摘要： Necrobiosis lipoidica (NL) represents a rare chronic granulomatous inflammatory skin disease of unknown etiology that is classically associated with diabetes. This cutaneous process is characterized by formation of yellow atrophic plaques with peripheral red-brown borders typically on the lower extremities which can occasionally ulcerate and significantly affect quality of life. NL has historically been and remains a difficult condition to treat, and therefore, a plethora of therapies have been reported in the literature: topical and intralesional glucocorticoids, topical calcineurin inhibitors, platelet aggregation inhibitors, various immunosuppressants, antimalarials, tumor necrosis factor-alpha inhibitors, phototherapy, photodynamic therapy, hyperbaric oxygen, and CO2 or pulsed dye laser (PDL) therapy. Regarding usage of PDL for treatment of NL, literature is limited, and treatment protocols are not well defined. To highlight efficacy of laser-based treatments in NL, we present an individual with a long-standing history of NL treated with PDL (Vbeam, 595-nm wavelength, 7.5-J/cm2 energy fluence, 7-mm spot size, and 6-ms pulse duration; Candela Corporation, Wayland, MA) with excellent cosmetic response.