研究目的
Investigating the efficacy of Photodynamic Therapy-ALA following fractional CO2 Laser as a treatment for vulvar Extramammary Paget’s Disease (EMPD).
研究成果
Photodynamic Therapy-ALA following fractional CO2 Laser does not seem to be an effective long-term treatment for vulvar EMPD, with only two out of ten patients maintaining complete remission at the 12-month follow-up. Further studies are needed to explore its efficacy as a palliative option for selected patients.
研究不足
The study's limitations include a small sample size of ten patients and the observation that only two patients maintained complete remission at the 12-month follow-up, indicating potential inefficacy of the treatment in the long term for vulvar EMPD.
1：Experimental Design and Method Selection:
The study involved treating ten patients with vulvar EMPD using a combination of fractional CO2 laser abrasion followed by photodynamic therapy with aminolaevulinic acid (ALA).
2：Sample Selection and Data Sources:
Patients were selected based on their diagnosis of noninvasive vulvar EMPD, with some having recurrence after surgical excision, medical contraindications to surgery, or refusal of surgical treatment.
3：List of Experimental Equipment and Materials:
A fractional CO2 laser with a wavelength of
4：600 nm, a cream containing 160 mg/g of methyl aminolevulinate, and an Aktilite CL 128 lamp (Galderma) for irradiation at 630 nm. Experimental Procedures and Operational Workflow:
The treatment involved laser irradiation, application of ALA cream, occlusion for 3 hours, and then irradiation with a 630-nm lamp at 100 J/cm2, repeated every 2 weeks for 5 times.
5：Data Analysis Methods:
Clinical examination was performed at follow-up visits at 2, 4, 6, and 12 months post-treatment to assess remission and recurrence.
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