摘要： Argyria (from the Greek word for silver, argyros) is the bluish gray discoloration of tissue caused by exposure to silver or its salts, often because of alternative medicine treatment or occasionally through occupational exposure. Since the 1990s, colloidal silver has been available in pharmacy-supplied dietary supplements and homeopathic remedies for the treatment of various diseases, including cancer, immunodeficiency, chronic fatigue, tuberculosis, and other infections, without any substantiating evidence. Long-term consumption of silver products can lead to chronic argyria, with silver deposition in organs, including the skin, liver, spleen, kidneys, and central and peripheral nervous system. Generalized argyria can occur when silver compounds are ingested, applied topically, or inhaled. Argyria can also be localized to certain sites of the skin or eyes if creams or eye drops are used or can be found on the ear lobes when silver earrings are worn. Silver deposits may localize in the eccrine glands of the skin, as well as in the papillary dermis and pilosebaceous follicles. The silver is in the form of silver sulfide and appears to be more abundant in the sun-exposed skin. Argyria has a well-defined toxicity, and discoloration is permanent. Recently, Q-switched nanosecond laser and picosecond alexandrite laser (PicoSure, Cynosure) have been used to treat argyria. Both the Q-switched nanosecond laser and the picosecond alexandrite laser use the principle of selective photothermolysis and have been used in a number of applications, including tattoo removal and pigmentation removal. Pulses of light energy is delivered to the skin and causes fragmentation of ink particles, allowing for phagocytosis and removal of the pigment by macrophages. It is speculated that laser treatment of argyria causes fragmentation of silver deposits in the skin, similar to the mechanisms of tattoo removal. We present a case report of the successful treatment of argyria with picosecond alexandrite laser, as demonstrated by clinical photographs, histopathology, and electron microscopy. This case provides evidence that picosecond laser causes the fragmentation of silver particles in argyria without phagocytosis in the immediate post-treatment phase.