研究目的
Investigating the applicability of exfoliated MXene (e-MXene) as a mediator for laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis of various analytes.
研究成果
The e-MXene exhibits high efficiency, resolution, and salt-tolerance for LDI-MS analysis of various analytes, making it a promising material for the development of an efficient analytical platform based on LDI-MS.
研究不足
The study focuses on the application of e-MXene for LDI-MS analysis, but the potential for optimization in terms of sensitivity and specificity for a wider range of analytes remains to be explored.
1：Experimental Design and Method Selection:
The study involved the preparation of e-MXene by DMSO intercalation and subsequent sonication in water, followed by characterization using SEM, TEM, DLS, UV–Vis spectroscopy, Raman spectroscopy, and XRD.
2：Sample Selection and Data Sources:
Various small molecules, including saccharides, amino acids, peptides, antibiotics, and organic pollutants, were selected for LDI-MS analysis.
3：List of Experimental Equipment and Materials:
MXene powder, DMSO, water, and various small molecules were used.
4：Experimental Procedures and Operational Workflow:
The e-MXene was prepared and characterized, then applied as a mediator for LDI-MS analysis of the selected small molecules under positive and negative ionization modes.
5：Data Analysis Methods:
The performance of e-MXene was evaluated based on desorption efficiency (DE) and survival yield (SY) using benzyl pyridium (BP) salt as a standard molecule.
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