研究目的
Investigating the photothermal properties of gold nanorods functionalized with silica layers of controllable thickness for therapeutic and diagnostic applications.
研究成果
The study demonstrates the importance of LIOAS measurements in the quantification of the heat generated from metallic nanoparticles in organic media. The experimental results are consistent with theoretical predictions, indicating that LIOAS is a reliable method for studying the photothermal effect in gold nanoparticles. The findings have significant implications for biomedical applications such as photothermal therapy.
研究不足
The study focuses on the photothermal properties of gold nanorods functionalized with silica layers, and the results may not be directly applicable to other types of nanoparticles or functionalization methods. The experimental and theoretical results showed small differences, attributed to variable size of Au-NRs and increased standard deviation of SiO2 thickness with their increasing size.
1：Experimental Design and Method Selection:
The study used time-resolved laser-induced optoacoustic spectroscopy (LIOAS) to determine the amount of absorbed energy changed promptly into heat. The heat generation efficiencies were simulated using the finite integration technique (FIT).
2：Sample Selection and Data Sources:
Gold nanorods (Au-NRs) functionalized with silica layers of controllable thickness (6, 8, 12, and 14 nm) were characterized by spectroscopic and microscopic methods.
3：List of Experimental Equipment and Materials:
Transmission electron microscopy (HR-TEM) using a JEOL ARM-200F instrument (200kV) and JEOL 1400 (120kV), UV-vis absorption spectra measured using a Varian Cary 4000 spectrometer.
4：Experimental Procedures and Operational Workflow:
The LIOAS setup was used with the excitation wavelength set to the longitudinal localized surface plasmon resonance band of Au-NRs (approx. 660 nm). The temperature of the samples during LIOAS measurement was kept constant at (20.00±0.01) °C.
5：00±01) °C.
Data Analysis Methods:
5. Data Analysis Methods: The fraction of absorbed energy released promptly as heat (α) for Au-NRs was calculated from the ratio of the slopes of linear dependencies of Hmax on Elas, obtained for the analyzed Au-NRs and reference.
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