研究目的
Investigating the thermal effects of laser ablation in the biliary tree for the treatment of unresectable cholangiocarcinoma, focusing on intraductal and surrounding tissue temperature achieved with different laser settings.
研究成果
The study demonstrates the feasibility of biliary tree laser ablation and highlights the importance of temperature monitoring for safety and efficacy. It suggests that equipping the laser probe with a temperature sensor could improve procedure control and safety, preserving the lumen and surrounding structures.
研究不足
The study's limitations include potential irreversible thermal damage to surrounding tissues due to high temperatures, variability in custom-made applicator performance, and underestimation of temperature effects in minimally invasive procedures compared to laparotomy access.
1：Experimental Design and Method Selection:
The study used a diode laser at 3 W and 5 W for 6 minutes on the common bile ducts of pigs. A custom-made laser applicator was used for circumferential ablation.
2：Sample Selection and Data Sources:
Two pigs were used, with ablations performed in the upper and lower portions of the common bile duct.
3：List of Experimental Equipment and Materials:
A diode laser, custom-made laser applicator, fiber Bragg grating (FBG) sensor, and infrared thermal camera were used.
4：Experimental Procedures and Operational Workflow:
After anesthesia and laparotomy, the common bile duct was isolated, and the laser applicator was inserted. Temperature was monitored during ablation.
5：Data Analysis Methods:
Tid values were extracted from FBG signals, and Tsup values were analyzed from thermal images, with noise filtered out.
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