摘要： In recent years, miRNA137 has shown great potential in inhibiting postoperative restenosis. In this paper, a mutual injection dual-output solid-state laser was used as the light source to construct a four-beam interferometric processing system to perform micro-nano processing on the surface of the metal coronary stent, which provides a good substrate for loading the miRNA137 onto the surface of the stent. The laser used in the experiment has a working wavelength of 1064 nm, and the energy of the two lasers is 183 mJ and 181 mJ, the energy of the four laser beams obtained by beam splitters is 97mJ, 83mJ, 95mJ and 82mJ respectively, the angle between the beams is 90 degrees and the exposure time is 60 s. When the incident angle is 14.52 degrees, a bionic micro/nano structure with a period of 3.077 μm is obtained. According to the preliminary comparative test, the structed stent with a period of 3.077μm has stronger adhesion property and longer drug release period to miRNA137 compared with the period of 1.063μm and 5.082μm.