研究目的
Investigating the therapeutic effects of a specific covalent organic polymer on generating singlet oxygen for potential applications in treating hypoxic tumors.
研究成果
The water-soluble COP designed and fabricated via a simple coupling method and RAFT polymerization can generate and bind singlet oxygen under red LED irradiation, releasing it upon heating above 110 ℃. This dual mechanism of singlet oxygen generation is promising for biomedical applications, especially in treating hypoxic tumors.
研究不足
The poor solubility of COPs in common solvents including water may limit their broad applications, especially in biomedical fields. The thermal stability of EPOs requires heating above 100 °C for cycloreversion, which could be a limitation for certain applications.
1：Experimental Design and Method Selection:
The COP was prepared by crosslinking TAPP with ADDA using EDC/DMAP coupling method, followed by modification with PPEGMEMA via RAFT polymerization.
2：Sample Selection and Data Sources:
The reactants TAPP and ADDA were used to synthesize COP, which was then characterized using ATR-FTIR, SEC, and TGA.
3：List of Experimental Equipment and Materials:
EDC, DMAP, TAPP, ADDA, PETTC, PEGMEMA, AIBN, and DMF were used.
4：Experimental Procedures and Operational Workflow:
The COP was synthesized, modified with PPEGMEMA, and its ability to generate and release singlet oxygen was tested under red LED irradiation and heating.
5：Data Analysis Methods:
UV-Vis spectroscopy, fluorescence spectroscopy, and hydrodynamic size measurement were used to analyze the COP's properties and singlet oxygen generation.
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