研究目的
To assess an easy to perform volumetric algorithm to detect and quantify papilledema in comparison to retinal nerve fiber layer (RNFL) analysis using optical coherence tomography (OCT).
研究成果
OCT-based volumetry of the optic nerve head discriminates very accurately between individuals with and without IIH. It may serve as a useful adjunct to the rating with the subjective and ordinal Frisén scale.
研究不足
Intracranial pressure measurements were not taken simultaneously or close to the OCT measurements. By using proprietary standard OCT software, segmentation errors and layer interpolations had to be corrected by subjective assessment and the corrections depended on best knowledge and judgment of the operator. The additional time expenditure of about 3 minutes may be a small limiting factor for the transition into clinical routine.
1：Experimental Design and Method Selection:
Participants with and without IIH underwent visual acuity testing at different contrast levels and static perimetry. Spectralis-OCT measurements comprised standard imaging of the peripapillary RNFL and macular ganglion cell layer (GCL). The optic nerve head volume (ONHV) was determined using the standard segmentation software and the 3.45 mm early treatment diabetic retinopathy study (ETDRS) grid, necessitating manual correction within Bruch membrane opening. Three neuro-ophthalmologists graded fundus images according to the Frisén scale. A mixed linear model (MLM) was used to determine differences between study groups. Sensitivity and specificity was evaluated using the area under the receiver-operating characteristic (ROC).
2：45 mm early treatment diabetic retinopathy study (ETDRS) grid, necessitating manual correction within Bruch membrane opening. Three neuro-ophthalmologists graded fundus images according to the Frisén scale. A mixed linear model (MLM) was used to determine differences between study groups. Sensitivity and specificity was evaluated using the area under the receiver-operating characteristic (ROC).
Sample Selection and Data Sources:
2. Sample Selection and Data Sources: Twenty-one patients with IIH and 25 controls were included in the study.
3：List of Experimental Equipment and Materials:
Spectralis-OCT (Heidelberg Engineering, Germany) with eye-tracking software (TrueTrack and NSite Axonal Analytics application, version 6.3.4.0).
4：0).
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The ONHV was measured between Bruch’s membrane (BM) and the inner limiting membrane (ILM) by superimposing the 3.45 mm ETDRS grid. Both the BM and ILM were delineated automatically by using the Heidelberg Eye Explorer (HEYEX, version 1.9.10.0).
5：45 mm ETDRS grid. Both the BM and ILM were delineated automatically by using the Heidelberg Eye Explorer (HEYEX, version 0).
Data Analysis Methods:
5. Data Analysis Methods: A mixed linear model (MLM) was used to determine differences between study groups. Sensitivity and specificity was evaluated using the area under the receiver-operating characteristic (ROC).
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