摘要： Optoregulated biointerfaces offer the possibility to manipulate the interactions between cell membrane receptors and the extracellular space. This Feature Article summarizes recent efforts of our group and others during the last decade in the development of light-responsive biointerfaces to stimulate cells and elicit cellular responses using photocleavable protecting groups (PPG) as working tool. This article begins by providing a brief introduction to available PPGs, with a special focus on the widely used o-nitrobenzyl family, followed by an overview of molecular design principles for the control of bioactivity in the context of cell-materials interactions, and the characterization methods to follow the photoreaction at surfaces. We present various light guided cellular processes using PPGs, including cell adhesion, release, migration, proliferation and differentiation, in vitro and in vivo. Finally, this feature article closes with our perspective view on the current status and future challenges of this topic.