研究目的
To study how the time-dependent IONP power dissipation can be used to optimize hyperthermia by increasing energy density in tumors while decreasing energy density in surrounding healthy tissue.
研究成果
Time-varying power dissipations from IONPs increase tumor temperature while decreasing surrounding healthy tissue temperature by increasing the temperature gradient at the edge of the tumor. The maximum power dissipation of IONPs plays a pivotal role in hyperthermia selectivity. Pmax should be placed toward the end of the treatment for optimal energy localization.
研究不足
The study is computational and does not account for all real-world variables in hyperthermia treatment, such as dynamic biological responses.
1：Experimental Design and Method Selection:
A finite element method was developed to solve the Penne’s bioheat transfer equation in the rectangular coordinate system, considering time-varying power input from IONPs.
2：Sample Selection and Data Sources:
The simulation incorporated the physical size and spatial location of each nanoparticle, placed according to a Gaussian probability function centered at the tumor.
3：List of Experimental Equipment and Materials:
Not explicitly mentioned.
4：Experimental Procedures and Operational Workflow:
The Crank–Nicolson scheme was used to solve the bioheat equation with a sufficiently fine mesh grid.
5：Data Analysis Methods:
The temperature gradient was used as the characterizing parameter of hyperthermia selectivity.
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