研究目的
To investigate the effects of high-definition transcranial direct current stimulation (HD-tDCS) on resting-state functional connectivity in the human prefrontal cortex using functional near-infrared spectroscopy (fNIRS).
研究成果
HD-tDCS increased functional connectivity in the prefrontal cortex, with greater effects in the stimulated hemisphere. The findings suggest that HD-tDCS can be used to enhance functional connectivity, which may be beneficial for neurorehabilitation in patients with degenerative brain diseases.
研究不足
The spatial resolution of fNIRS was a limitation, and the absence of short separation channels could have helped remove skin-related artifacts. Future studies could incorporate the bundled optode approach for better spatial resolution and include short separation channels to exclude skin artifacts.
1：Experimental Design and Method Selection:
The study involved 15 healthy male subjects who underwent HD-tDCS while their prefrontal cortex activity was monitored using fNIRS. The experiment consisted of three phases: prestimulation, stimulation, and poststimulation.
2：Sample Selection and Data Sources:
Subjects were healthy males aged
3：5 ± 5 years with no history of neurological or psychiatric disorders. List of Experimental Equipment and Materials:
A Starstim tCS system for HD-tDCS and a DYNOT fNIRS imaging device were used.
4：Experimental Procedures and Operational Workflow:
The experiment lasted 25 minutes, divided into a 5-minute prestimulation phase, a 10-minute stimulation phase, and a 10-minute poststimulation phase. fNIRS data were collected throughout.
5：Data Analysis Methods:
Pearson correlation coefficients were calculated from ΔHbO signals, and graph theory metrics were computed to evaluate network changes.
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