研究目的
Investigating the effect of gold nanoparticles (GNPs) in a tumor during X-ray therapy.
研究成果
Radiation therapy of cancerous cells in the presence of GNPs is more effective than pure irradiation. Gold atoms increase the production of secondary electrons and photons in cancerous cells, causing serious damage to cancer cells and stopping cell division. The best GNP size for X-ray therapy is around 50 nm in diameter, and suitable X-ray energy should be used in the energy range between 20 keV and 150 keV.
研究不足
The study focuses on the simulation of a spherical tumor and the effect of GNPs during X-ray therapy. The actual application may vary based on tumor shape, size, and location in the body.
1：Experimental Design and Method Selection:
The study is based on the Monte Carlo method using the Geant4 software toolkit for the simulation of the passage of particles through matter. The Penelope physics model was used for reliable results for energies down to a few hundred eV and up to 1 GeV.
2：Sample Selection and Data Sources:
A spherical tumor localized in the center of a human head and a spherical GNP in the center of a water cube with a volume of 20 μm3 were simulated.
3：List of Experimental Equipment and Materials:
Geant4 software toolkit, gold nanoparticles.
4：Experimental Procedures and Operational Workflow:
The human head is exposed to an X-ray placed 1 m from the patient. The absorbed dose in the tumor and the effect of GNPs on the absorption of X-ray beams at the cellular level were investigated.
5：Data Analysis Methods:
The absorbed dose and energy were calculated and plotted versus X-ray energy and GNP size.
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