研究目的
To investigate which measurements of inner macular thickness are the most useful for evaluating the focal relationship with visual sensitivity within the central 108 in glaucoma and which layers require correction for retinal ganglion cell (RGC) displacement.
研究成果
The GCC is the most useful parameter to evaluate structure and function within the central 108 of the macula in glaucoma. Adjusting for RGC displacement is essential to evaluate the relationship between structure of the GCL-related layer and function at the central macula.
研究不足
1. Although inner retinal thickness (GCC) decreases with age and the sensitivity of SAP decreases with age, the effect of age was not considered. 2. Eye movements and ocular rotation were not considered. 3. The study did not have a normal database of GCL, so macular structural deficits of the GCL were not validated.
1：Experimental Design and Method Selection:
The study included sixty eyes of sixty subjects with glaucoma. Sensitivity of each test point of 10-2 standard automated perimetry was compared with the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL + inner plexiform layer (IPL), and RNFL + GCL + IPL (GCC), with and without RGC displacement, using Spearman’s rank correlation coefficients. Visual sensitivity was evaluated by unlogged 1/Lambert (1/L) values.
2：Sample Selection and Data Sources:
Glaucoma patients who had experienced more than three 24-2 SAP or 10-2 SAP tests were enrolled in this study from January 2010 to July
3：List of Experimental Equipment and Materials:
20 Spectral domain OCT examinations were performed with a 3D OCT 2000 version 7 (Topcon, Inc., Tokyo, Japan).
4：Experimental Procedures and Operational Workflow:
All participants underwent ocular examination, including autorefractometer measurements without cycloplegic agents, best-corrected visual acuity measurements with a 5-meter Landolt chart, slit-lamp examination, IOP measurements using a Goldmann applanation tonometer, dilated funduscopy, visual field testing using the Humphrey 24-2 Swedish Interactive Threshold Algorithm (SITA) Standard Strategy (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA, USA), and 10-2 SITA Standard Strategy (Humphrey Field Analyzer), and SD-OCT examination with a 3D OCT 2000 version 7 (Topcon, Inc., Tokyo, Japan).
5：Data Analysis Methods:
Spearman’s rank correlation coefficients were used to evaluate the relationship between visual sensitivity at each test point and the thickness of the retinal layers.
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