研究目的
To achieve rapid and sensitive recognition of norepinephrine (NE) in complicated organism using a facile ferric citrate (CA‐Fe (III)) sensor by surface‐enhanced resonance Raman spectroscopy (SERRS) method.
研究成果
The developed SERRS strategy provides a sensitive and selective method for NE detection in biofluids, with potential applications in the analysis of other neurotransmitters and complex systems.
研究不足
The study is limited by the need for a pretreatment method to purify and enrich NE in complex biological samples, and the detection is only effective in neutral or acidic environments.
1：Experimental Design and Method Selection:
The study involved the synthesis of uniform Au nanoparticles (NPs) by seed growth method, preparation of SERRS active substrate by modifying Fe (III) on the surface of Au NPs, and development of a pretreatment method for NE detection in biofluids.
2：Sample Selection and Data Sources:
Serum and tissue fluids were used as biofluid samples.
3：List of Experimental Equipment and Materials:
Included HAuCl4?4H2O, sodium citrate, Fe (NO3)3?9H2O, and others.
4：Experimental Procedures and Operational Workflow:
Detailed steps for synthesis, substrate preparation, and pretreatment method were followed.
5：Data Analysis Methods:
Raman spectral measurements were conducted using a confocal Raman spectrometer.
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