摘要： Recent outbreaks of the Ebola virus infection in several countries demand a rapid point-of-care (POC) detection strategy. This paper reports on an innovative pathway founded on electronic resonance frequency modulation to detect Ebola glycoprotein (GP), based on carrier injection-trapping-release-transfer mechanism and standard antibody-antigen interaction principle within a dielectric-gated reduced graphene oxide (rGO) field-effect transistor (GFET). The sensitivity of the current Ebola detection can be significantly enhanced by monitoring the device’s electronic resonance frequency, such as inflection frequency (fi), where phase angle reaches maximum (θmax). In addition to excellent selectivity, a sensitivity of ~36-160 % and ~17-40 % for 0.001-3.401 mg/L Ebola GP can be achieved at high and low inflection resonance frequencies, respectively, which are several orders of magnitude higher than the sensitivity from other electronic parameters (e.g., resistance-based sensitivity). Using equivalent circuit modelling on contributions of channel and contact, analytical equations for resonance shift have been generalized. When matching with the incoming ac measurement signal, electronic resonance from the phase angle spectrum is evolved from various relaxation processes (e.g., trap and release of injected charge at surface trap sites of channel-gate oxide and channel-source/drain interface) that are associated with a characteristic emission frequency. Using charge relaxation dynamics, a high-performance bio-FET sensing platform for healthcare and bio-electronic applications is realized through resonance shifting.