研究目的
Quantification of transcutaneous blood oxygen saturation (StO2) via a noninvasive approach using Extended Modified Lambert Beer (EMLB) model.
研究成果
The developed spectroscopy system and quantification technique can potentially be used as an alternative means to clinical assessment of wound healing progress, with a mean StO2 value of 75 ± 5% observed in the study.
研究不足
The accuracy of the method is dependent on the assumption that hemoglobin and oxyhemoglobin are the only absorbing medium in blood. The study also lacks a gold standard for comparison of the measured StO2 values.
1：Experimental Design and Method Selection:
The study employed a Continuous wave (CW) reflectance spectroscopy system for noninvasive estimation of StO2 using the EMLB model.
2：Sample Selection and Data Sources:
Measurements were taken from the left index finger of an Asian nonsmoking volunteer at resting condition.
3：List of Experimental Equipment and Materials:
The system included a high intensity LED (XLamp? XQ-E LED from Cree), a monochromator (Oriel Mini Monochromator model 78026 from Newport), and a cooled CCD camera (BUC4-500C Cooled CCD Digital Camera from BestScope).
4：Experimental Procedures and Operational Workflow:
Multispectral images were captured in the wavelength range of 520 ? 600 nm at an interval of 10 nm. The data was analyzed using a fitting algorithm to estimate StO
5：Data Analysis Methods:
The attenuation data was fitted using the EMLB model with an iterative fitting procedure in MATLAB to solve for optimal values of nonlinear unknown parameters.
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