研究目的
To investigate the implications of using human tissue compositions for dose calculations in mice for kilovoltage photon beams.
研究成果
This study illustrates the need for murine reference tissue data. However, assigning only a single mean reference value to an entire tissue can still lead to large errors in dose calculations given the large spread within tissues of μen/ρ values found in this study. Therefore, new methods such as DECT and spectral CT imaging need to be explored, which can be important next steps in improving tissue assignment for dose calculations in small animal radiotherapy.
研究不足
The accuracy of the extracted Zeff and ρe is influenced by imaging noise, beam hardening, and other imaging artifacts such as scatter, partial volume effects, and motion of the animal.
1：Experimental Design and Method Selection:
Dual energy CT (DECT) images of 9 female mice were used to extract the effective atomic number Zeff and the relative electron density ρe for each voxel in the images.
2：Sample Selection and Data Sources:
A total of 10 tissues were contoured by a radiation oncologist using the clinical treatment planning software Eclipse.
3：List of Experimental Equipment and Materials:
The X-RAD 225Cx system was used to image the mice.
4：Experimental Procedures and Operational Workflow:
Two CBCT images were acquired with two different peak voltages: 50 and 90 kVp. The acquired images were reconstructed using the Feldkamp backprojection algorithm.
5：Data Analysis Methods:
Mass energy-absorption coefficients μen/ρ were calculated for 10 different tissues in each mouse.
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