研究目的
To propose an analytical method to compute the fiber orientation distribution function (ODF) from high-resolution vector data provided by 3D-PLI, enabling the bridging of high resolution 3D-PLI to diffusion magnetic resonance imaging with relatively low spatial resolution.
研究成果
The proposed method for reconstructing the fiber orientation distribution function from high-resolution 3D-PLI datasets outperforms previous methods by improving the angular resolution of recovered fiber ODFs and reducing angular error at high SH Lmax. This opens the door to aligning high-resolution 3D-PLI data to dMRI data for multimodal data analysis at voxel level.
研究不足
The angular error depends on the technique used to find the peaks of the ODF and can be ameliorated.
1：Experimental Design and Method Selection:
The fiber ODF is modeled as a sum of K orientations on the unit sphere and expanded with a high order spherical harmonics series. The coefficients of the spherical harmonics are derived directly with the spherical Fourier transform.
2：Sample Selection and Data Sources:
Synthetic data and post-mortem human heart data from a healthy adult were used.
3：List of Experimental Equipment and Materials:
Not explicitly mentioned.
4：Experimental Procedures and Operational Workflow:
The method was quantitatively validated against synthetic data and applied to human heart data to recover complex fiber configurations at different scales.
5：Data Analysis Methods:
The accuracy of the reconstruction was validated, and the ability to recover complex fiber configurations was demonstrated.
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