研究目的
To compare electrical and optogenetic neuromodulation capabilities of the subthalamic nucleus in terms of firing rates, strength-duration curves, and action potential shape.
研究成果
Optogenetic stimulation offers higher spatial resolution but is less efficient and results in a smaller firing rate dynamic range compared to electrical stimulation. The action potential shape is not significantly affected by the choice of stimulation modality.
研究不足
The study is based on computational models, which may not fully replicate the complexity of biological systems. The impact of noise on firing rates is not considered.
1：Experimental Design and Method Selection:
The study combines the Otsuka-model for simulating a plateau-potential generating STN-neuron and the Williams-model for simulating optogenetic neuromodulation. The models are implemented in Matlab with specific functions for electrical and optogenetic stimulation.
2：Sample Selection and Data Sources:
Computational models are used, with no physical samples.
3：List of Experimental Equipment and Materials:
Matlab software for simulations.
4：Experimental Procedures and Operational Workflow:
Simulations are conducted with imposed discretization steps and tolerances for optical and electrical stimulation.
5：Data Analysis Methods:
Mean spiking frequency and mean instantaneous firing rate are calculated, and strength-duration curves are fit with the Hill-Lapicque equation.
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