研究目的
To demonstrate segmentation and mapping of corneal layers (epithelium, Bowman’s layer, and stroma) across the entire cornea (limbus to limbus), using additional contrast provided by polarization-sensitive optical coherence tomography (PS-OCT) and analyze the reproducibility of the procedure.
研究成果
PS-OCT with conical scanning is a feasible approach for determining thickness maps of corneal layers on a large ?eld of view with high reproducibility.
研究不足
Only healthy eyes were included in the study. The algorithms may need adaptation for corneas with smaller radius of curvature or for patients with diseases such as keratoconus.
1：Experimental Design and Method Selection:
A custom built PS-OCT system operating at 1045 nm central wavelength with conical scanning was used for image acquisition. Conical scanning allows for almost perpendicular beam incidence on the corneal surface and provides good signal quality over the entire ?eld of view.
2：Sample Selection and Data Sources:
Both eyes of 20 healthy volunteers were imaged at least three times.
3：List of Experimental Equipment and Materials:
A custom built, single-mode ?ber based swept-source PS-OCT prototype operating at a central wavelength of 1045 nm with a spectral bandwidth of 100 nm was used for imaging.
4：Experimental Procedures and Operational Workflow:
Epithelium, Bowman’s layer, and stroma were segmented using the additional contrast provided by PS-OCT. Thickness maps were computed and analyzed in sectors.
5：Data Analysis Methods:
Thickness maps were computed and analyzed in sectors. The reproducibility of thickness measurements was quantified.
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