研究目的
Investigating the influence of synthesis parameters on the size and distribution of silica nanoparticles (SNPs) prepared from biomass (rice husk) and chemical precursors (TEOS), and their functionalization with porphyrin nanoparticles for bioimaging applications.
研究成果
The study successfully synthesized silica nanoparticles from rice husk and TEOS, demonstrating the influence of ethanol concentration on particle size and distribution. Functionalization with porphyrin nanoparticles showed potential for bioimaging applications, with rice husk-derived SNPs exhibiting higher binding affinity. The photoluminescence properties of the functionalized SNPs suggest their utility in theranostic applications, pending further drug conjugation studies.
研究不足
The study highlights the agglomeration of rice husk-derived SNPs, which affects their size distribution and optical properties. The choice of silica precursors and solvent concentration significantly influences the particle size and shape, indicating potential areas for optimization in synthesis parameters.
1：Experimental Design and Method Selection:
The study employed the Stober method for the synthesis of silica nanoparticles (SNPs) from rice husk and TEOS, focusing on the effects of ethanol and water concentration on particle size and distribution. Porphyrin nanoparticles were prepared using a solvent mixing technique and functionalized onto the SNPs.
2：Sample Selection and Data Sources:
Rice husk was procured from a mill in Chennai, India. Chemical precursors including TEOS, ammonia solution, ethanol, and protoporphyrin IX disodium salt were procured from Sigma Aldrich, India.
3：List of Experimental Equipment and Materials:
Fourier transform infrared spectroscopy (FTIR) (JASCO FT/IR-6600), scanning electron microscopy (SEM) (SEM hitachi N3400, Singapore), UV-Vis spectroscopy (Perkin Elmer Lambda 35), and Fluorolog (Fluorolog Horiba Jobin Yvon) were used for characterization.
4：Experimental Procedures and Operational Workflow:
Silica was extracted from rice husk through acid and thermal treatments. SNPs were synthesized via the Stober method with varying ethanol to water ratios. Porphyrin nanoparticles were functionalized onto the SNPs, and the binding affinity was analyzed using UV-Vis spectroscopy.
5：Data Analysis Methods:
The binding constant and dissociation constant between silica and porphyrin nanoparticles were calculated using UV-Vis spectroscopy data. Photoluminescence studies were conducted to analyze the emission properties.
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