研究目的
Investigating the design of a nanoplatform capable of dual-modal imaging and synergetic antitumor cells therapy by overcoming luminescence quenching at high doping concentrations in lanthanide materials.
研究成果
The designed UCNP combining Er3+ assisted energy migration and an active core@shell structure exhibited red UCL of Er3+ upon NIR excitation. After coating a mesoporous silica layer and storing the therapy agents of ZnPc, the emission light transmit energy to ZnPc, which provides 1O2. In vitro results indicate that the sample exhibits an efficacious tumor inhibition effect and dual-modal imaging (UCL and NIR-II).
研究不足
The study focuses on the synthesis and characterization of nanoparticles with high Er3+ doping concentrations and their application in photodynamic therapy, but the practical application in vivo may face challenges such as biocompatibility and targeted delivery.
1：Experimental Design and Method Selection:
The study involved the synthesis of NaYF4:x%Er@NaXF4 core@shell nanoparticles with varying Er3+ ion concentrations and the examination of their luminescence properties under NIR excitation.
2：Sample Selection and Data Sources:
Nanoparticles were synthesized with Er3+ ion concentrations of 5, 25, 50, and 100 mol %.
3：List of Experimental Equipment and Materials:
Transmission electron microscopy (TEM), Edinburgh FLS980 spectrometer, 980 or 808 nm continuous-wave (CW) diode lasers, and various chemicals including YCl3, ErCl3, LuCl3, etc.
4：Experimental Procedures and Operational Workflow:
Synthesis of core nanoparticles, synthesis of core@shell nanoparticles, phase transfer of UCNP@mSiO2, preparation of UCNP@mSiO2?ZnPc, and characterization.
5：Data Analysis Methods:
Luminescence spectra and luminescence decays were measured, and viability of MCF-7 cells was assessed using MTT assay.
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