研究目的
To evaluate with RCM atypical melanocytic lesions identified in dermoscopy, according to common RCM criteria for the differential diagnosis of BCC, and to identify representative RCM parameters for superficial (sBCCs) and nonsuperficial (nsBCCs) basal cell carcinomas (BCCs).
研究成果
RCM has been proven to be an optimal, noninvasive examination for early differential diagnosis, and this study underlines its application to BCCs with atypical dermoscopy presentations mimicking MM. Further, RCM seems able to assist in differential diagnoses of sBCCs or nsBCCs in this group of atypical BCCs, offering the opportunity to enhance therapeutic and patient management in the clinical setting.
研究不足
The absence in literature of a dermoscopy classification of atypical BCCs, but typical BCC RCM criteria proved useful in identifying this equivocal subset of atypical BCCs. Further, the limited ability of RCM in vascular morphology and vessel diameter evaluation made this feature difficult to assess, and the integration of optical coherence tomography analysis should be considered for future research dedicated to in vivo diagnosis of atypical BCC.
1：Experimental Design and Method Selection:
A retrospective analysis of consecutive patients evaluated with RCM, selecting excised lesions classified at dermoscopy with ≥1 score from the revisited 7-point checklist, mimicking melanoma, registered between 2010 and 2016. Cluster analysis identified BCC subclassifications.
2：Cluster analysis identified BCC subclassifications.
Sample Selection and Data Sources:
2. Sample Selection and Data Sources: Of 178 consecutive lesions registered at RCM in the study period with at least one of the features of atypical melanocytic lesions evidenced with dermoscopy and without specific features for other lesions, a total of 34 cases were classified at RCM retrospective analysis as BCCs.
3：List of Experimental Equipment and Materials:
Reflectance confocal microscopy (RCM) was used for in vivo imaging at nearly histological resolution.
4：Experimental Procedures and Operational Workflow:
Retrospective analysis of RCM images found an association between specific RCM features and BCC diagnoses in the dermoscopically equivocal group mimicking MM.
5：Data Analysis Methods:
Hierarchical cluster analysis identified 2 clusters, according to the highest pseudo F statistic.
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