研究目的
To compare the sensitivity and depth resolution of IVPA-US and NIRS-IVUS in detecting arterial lipid in early and late-stage atherosclerosis.
研究成果
IVPA-US has the capability to quantify and localize plaque lipid cores with calcification, providing depth resolution that NIRS-IVUS lacks. This enables more accurate longitudinal studies monitoring plaque progression and regression.
研究不足
The study is limited by the lack of intimal lipid in the iliac arteries of Ossabaw swine and the small sample size of human artery specimens. Future studies aim to address these limitations with longer duration MetS phenotypic development and a larger calibration data set.
1：Experimental Design and Method Selection:
The study involved in vivo and ex vivo imaging of iliac arteries in Ossabaw swine with metabolic syndrome (MetS) and lean swine, and ex vivo imaging of a human coronary artery. Both IVPA-US and NIRS-IVUS modalities were used for comparison.
2：Sample Selection and Data Sources:
Ossabaw swine with MetS and lean swine were used for early-stage atherosclerosis study. A fresh human coronary artery was used for late-stage atherosclerosis study.
3：List of Experimental Equipment and Materials:
IVPA-US imaging system with a nanosecond Nd:YAG pumped optical parametric oscillator excitation laser source, NIRS-IVUS system, and histological staining materials.
4：Experimental Procedures and Operational Workflow:
In vivo and ex vivo imaging procedures were performed, followed by histological analysis for validation.
5：Data Analysis Methods:
Quantitative analysis of lipid area and core volume was performed using MATLAB software. Statistical analysis was conducted using GraphPad Prism statistical software.
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