研究目的
To synthesize and characterize a new Schiff base derived from 2-amino-6-methoxybenzothiazole and 2-hydroxy-4,6-dimethoxybenzaldehyde, and to study its biological activities, DNA interaction, and colorimetric anion sensing applications.
研究成果
The synthesized Schiff base exhibited significant biological activities, DNA binding and cleavage properties, and colorimetric sensor capabilities for fluoride and cyanide anions. The compound's potential applications in antimicrobial therapy and anion sensing were demonstrated.
研究不足
The study is limited to in vitro experiments and computational modeling. Further in vivo studies are needed to confirm the biological activities and potential therapeutic applications.
1：Experimental Design and Method Selection:
The Schiff base was synthesized and characterized using elemental analysis, FTIR, UV-VIS, NMR, and single crystal X-ray diffraction techniques. Molecular modeling methods were used to study frontier molecular orbitals, molecular electrostatic potential, and chemical reactivity descriptors.
2：Sample Selection and Data Sources:
The compound was prepared from 2-amino-6-methoxybenzothiazole and 2-hydroxy-4,6-dimethoxybenzaldehyde. Antimicrobial activities were tested against various microorganisms.
3：List of Experimental Equipment and Materials:
Bruker DPX FT-NMR spectrometer, T80 + UV/VIS Spectrometer, Fluorescence spectrometer, Perkin Elmer BX II spectrometer, Vario EL III CHNS elemental analyzer, Electro-Thermal IA 9100 apparatus.
4：Experimental Procedures and Operational Workflow:
The compound was synthesized by refluxing the reactants in ethanol, followed by crystallization. Antimicrobial activities were determined using the broth microdilution method. DNA interaction studies were conducted using UV-VIS spectra and gel electrophoresis.
5：Data Analysis Methods:
UV-VIS spectral titrations, gel electrophoresis, and computational studies using DFT/B3LYP method.
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