摘要： Objective: To explore new therapies for castration-resistant prostate cancer (CRPC) to improve patients’ quality of life and extend life. Materials and Methods: The synthesis, morphology analysis, phase analysis, spectral analysis and photothermal conversion test were referenced to our previous articles. Then NIR-light-driven CuS nanoplates to inhibit the growth of prostate cancer cells in vivo and in vitro was carried out. Transmission electron microscope, mCherry-LC3 syncytial virus labelling, acridine orange staining and autophagy protein were used to detect the autophagy caused by CuS nanoplates and chloroquine was used to inhibit the process of autophagy. Results: The CuS nanoplates prepared in this study feature low cytotoxicity, simple preparation and high photothermal conversion efficiency. Driven by 980nm near-infrared light, CuS nanoplates could inhibit the growth of prostate cancer cells in vivo and in vitro, while triggering the autophagy and cytoprotection of prostate cancer cells. Conclusions: CuS nanoplates are a kind of commendable photothermal therapy agent in CRPC treating. Autophagy inhibition enhances the photothermal efficiency of CuS nanoplates, which indicates favorable application prospects in the treatment of advanced prostate cancer.