研究目的
To evaluate the utility of ring-type dedicated breast positron emission tomography (dbPET) for the detection of the residual tumor after neoadjuvant chemotherapy (NAC).
研究成果
The dbPET was superior to WBPET for the detection of residual tumor after NAC.
研究不足
First, we used only the ring-type dbPET. This has a relatively large blind area adjacent to the pectoral muscle. Asian countries have a greater number of patients with small breasts than is the case in Western countries. In such patients, some residual tumor was present but out of the imaging range. This limitation may lead to the misdiagnosis of tumor remnants or an incorrect evaluation of their extent. Second, our sample size was relatively small. Only 27 cases were included in the study population and there were only eight pCR tumors. The influence of selection bias may be great.
1：Experimental Design and Method Selection:
This prospective study included 27 women with histologically proven breast cancer over a 37-month period. All patients underwent ring-type dbPET followed by whole-body PET-CT (WBPET) for preoperative tumor evaluation and re-staging after NAC.
2：Sample Selection and Data Sources:
Patients with breast cancer who underwent both conventional whole-body PET-CT (WBPET) and ring-type dbPET for preoperative tumor assessment and re-staging after NAC at our institution.
3：List of Experimental Equipment and Materials:
WBPET was performed with an Eminence SOPHIA PET scanner (Shimadzu, Kyoto, Japan) and dbPET with an Elmammo system (Shimadzu, Kyoto, Japan).
4：Experimental Procedures and Operational Workflow:
The patient was instructed to fast for at least 6 h prior to the scan. 18F-FDG was injected intravenously at a dose of
5：1 mCi (7 MBq)/kg body weight, and 45 min later, the WBPET was acquired in the mid-expiration phase of free breathing, with continuous bed motion at a speed of 0 mm/s. Once the WBPET image acquisition was complete, dbPET was performed with the patient in a prone position with her breast hanging down into the ring-type detector. Data Analysis Methods:
A radiologist placed a region of interest (ROI) that encompassed the entire tumor on the WBPET and dbPET axial images using a commercially available Digital Imaging and Communications in Medicine viewer, and measured the maximum standardized uptake value (SUVmax) for each modality.
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