摘要： Several telescopes include large deformable mirrors (DM) located directly inside the telescope. These adaptive telescopes trigger new constraints for the calibration of the adaptive optics (AO) systems as they usually offer no access to an artificial calibration source for the interaction matrix measurement. Moreover, the optical propagation between the DM and the wavefront sensor (WFS) may evolve during the operation, resulting in misregistrations that highly affect the AO performance and thus the scientific observation. They have to be measured and compensated, for instance by updating the calibration. A new strategy consists of estimating the misregistrations and injecting them into synthetic models to generate noise-free interaction matrices. This pseudo-synthetic approach is the baseline for the adaptive optics facility working with a Shack–Hartmann WFS and seems particularly suited for the future Extremely Large Telescope as the calibration will have to be regularly updated, for a large numbers of actuators. In this paper, the feasibility of a pseudo-synthetic calibration with pyramid WFS at the Large Binocular Telescope (LBT) is investigated. A synthetic model of the LBT AO systems is developed, and the procedure to adjust the misregistrations parameters is introduced, extracting them from an experimental interaction matrix. We successfully tested an interaction matrix generated from the model on the real system in high-order AO mode. We recorded a slightly better performance with respect to the experimental one. This work demonstrates that a high-accuracy calibration can be obtained using the pseudo-synthetic approach with pyramid WFS.