研究目的
To use color Doppler to analyze blood ?ow in the retrobulbar central retinal artery (CRA) and central retinal vein (CRV) in monocular retinoblastoma and to correlate these findings with high-risk pathologic features.
研究成果
Tumor volume was directly correlated with CRAv and RIa, and lower PIv was correlated with optic nerve invasion when a predictive cut-off value of less than 0.935 was applied. Comparisons with healthy eyes showed that tumor-containing eyes were associated with higher RIa and PIv values.
研究不足
The study was limited to patients with group D and E retinoblastomas managed with only enucleation. The sample size was relatively small (25 patients).
1：Experimental Design and Method Selection:
Prospective study including patients with group D and E retinoblastomas managed with only enucleation. Peak blood velocities were assessed in the CRA and CRV of tumor-containing eyes. The resistivity index in the CRA (RIa) and pulse index in the CRV (PIv) were calculated and related to optic nerve invasion (ONi), choroid invasion (mCHi), and tumor volume.
2：Sample Selection and Data Sources:
25 patients with a mean age of
3：8-months old were included. List of Experimental Equipment and Materials:
Orbital MRI study was performed at
4：5 T (HDxt, General Electric [GE], Milwaukee, WI, USA) with a standard head coil. US and CDI were performed using a Toshiba Aplio XG and Toshiba Aplio 500 (Tokyo, Japan) with a 16-MHz transducer. Experimental Procedures and Operational Workflow:
The examination was performed along the longitudinal and transverse axes while the patient’s eyes were closed and covered with a large amount of US gel. Tumor diameter was assessed three times, and the arithmetic mean was determined.
5：Data Analysis Methods:
Statistical tests were conducted using SPSS 17.0 for Windows.
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