研究目的
Determining the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma.
研究成果
The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.
研究不足
The study excluded individuals with poor visual acuity and non-glaucomatous visual field defects, which may underestimate the rate of co-morbid macular pathology and scan artefact in clinical practice.
1：Experimental Design and Method Selection:
A prospective study assessing predictors of glaucoma progression was conducted. Macular GCIPL imaging was performed using the CIRRUS HD-OCT.
2：Sample Selection and Data Sources:
1439 eyes from 721 subjects with suspect glaucoma or early manifest glaucoma were included. Exclusion criteria included visual acuity of less than 6/18 in the affected eye, and visual field defect not attributable to glaucoma.
3：List of Experimental Equipment and Materials:
CIRRUS HD-OCT (Carl Zeiss Meditec, Dublin, CA) was used for macular cube 512x128 scans.
4：Experimental Procedures and Operational Workflow:
All subjects had pupil dilation with tropicamide 1% before the scans were performed. Scans were analyzed with the commercially available GCA software.
5：Data Analysis Methods:
Scans were independently reviewed by two glaucoma consultants for evidence of acquisition error, segmentation artefact, or identifiable co-morbid macular pathology.
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