研究目的
To develop and evaluate a flexible ECoG array with PEDOT: PSS coated electrodes for chronic recording and electrical stimulation in the visual cortex of macaque monkeys, aiming to reduce invasiveness and improve signal quality.
研究成果
The developed flexible ECoG array with PEDOT: PSS coated electrodes is suitable for chronic recording in the visual cortex, demonstrating stable neural recordings over extended periods. The array's design and material properties make it a promising tool for bidirectional neural interfacing, though further work is needed to optimize its long-term performance and stimulation capabilities.
研究不足
The study notes a significant increase in electrode impedance over time and variability in the performance of individual electrodes. The long-term stability and effectiveness of electrical stimulation through the same electrodes require further investigation.
1：Experimental Design and Method Selection:
The study involved the design and fabrication of a flexible ECoG array with 202 electrodes coated with PEDOT: PSS for chronic recording in visual cortical areas V1 and V4. The array's layout was optimized to fit the curved surface of the brain.
2：The array's layout was optimized to fit the curved surface of the brain.
Sample Selection and Data Sources:
2. Sample Selection and Data Sources: The array was implanted epidurally in macaque monkeys. Neural activity was recorded during a fixation task with moving bars to estimate visual receptive fields.
3：List of Experimental Equipment and Materials:
A flexible ECoG array with PEDOT: PSS coated electrodes, Omnetics SMD connectors, and a bipolar current stimulator for electrical stimulation experiments.
4：Experimental Procedures and Operational Workflow:
The array was implanted chronically, and its functionality was assessed through impedance spectroscopy and recording of neural activity over time.
5：Data Analysis Methods:
Impedance measurements were analyzed using an equivalent circuit model. Neural activity was analyzed to estimate visual receptive fields.
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