研究目的
To dynamically detect and monitor drug-induced diabetes on a group of mice using mm-wave spectroscopy, aiming for non-invasive detection of hyperglycemia typically associated with diabetes.
研究成果
The proposed mm-wave spectroscopy technique can accurately detect sustained hyperglycemia associated with diabetes after fourteen days of occurrence in animal models. It shows potential for monitoring sustained glycemic trends with a few days between assessments, offering a non-invasive alternative to current methods.
研究不足
The exact period needed for detecting changes in the glucose metabolism and the magnitude of those changes required for detection are still not known. The study was conducted on animal models, and further clinical trials are needed to validate the method in humans.
1：Experimental Design and Method Selection:
The study used mm-wave spectroscopy in the W-band for non-invasive detection of hyperglycemia in mice. The method involved analyzing the transmittance of a fold of skin at the animals’ nape.
2：Sample Selection and Data Sources:
The study involved healthy C57Bl6/J mice as control cases and Lepdb/Lepdb (diabetic) mice as diabetic cases. Additionally, nine C57Bl6/J mice were submitted to a drug-induced diabetes process.
3：List of Experimental Equipment and Materials:
The spectrometer setup included an AFM6-110 Active Frequency Multiplier, HMR-110-6 W-band receivers, and an acquisition card (Handyscope HS4-10).
4：0).
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Mice were anesthetized, and spectral interrogation was performed non-invasively on a folded skin on the nape of the mice. The spectral data was analyzed using Functional Principal Component Analysis (FPCA).
5：Data Analysis Methods:
The spectral data was approximated by continuous functions using regression splines on cubic B-splines basis. FPCA was performed to explore and highlight the variance between spectra.
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