研究目的
To develop a quantitative model for estimating the scale of photochemically induced ischemic stroke by simulating light penetration and scattering in brain tissue.
研究成果
The proposed quantitative model effectively simulates light intensity distribution in brain tissue for photothrombotic procedures, offering a tool for researchers to estimate the scale of infarction and optimize light beam parameters for desired lesion characteristics. Future work will focus on model calibration and integration with animal models for micro cortical strokes.
研究不足
The model's numerical precision could be improved, especially for wavelengths with less-than-ideal computational results. Additionally, the study suggests future calibration based on pathology examination to bridge potential mismatches between simulation and histology observation.
1：Experimental Design and Method Selection:
The study employed an analytical model based on McLean’s light beam spread function method to simulate light distribution in brain tissue.
2：Sample Selection and Data Sources:
Mouse brain tissue parameters associated with different wavelengths (532 nm and 560 nm) were used in simulations, chosen according to the absorption spectrum of Rose Bengal.
3：List of Experimental Equipment and Materials:
The model utilized parameters defining the optical characteristics of cortical tissue, including refractive index, scattering and absorption coefficients, and anisotropy coefficient.
4：Experimental Procedures and Operational Workflow:
The model calculated the spatial-temporal light intensity distribution from a pulse source, normalized to its energy, and performed temporal integration and spatial convolution to estimate photon density and spatial extent of light exposure.
5：Data Analysis Methods:
The study analyzed light intensity distribution, penetration depth, and transmittance to estimate the scale of infarction in photothrombosis protocols.
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