研究目的
To design, fabricate, and evaluate novel materials to remove silicone oil (SiO) droplets from intraocular lenses (IOL) during vitreoretinal surgery.
研究成果
Removal of SiO from IOLs can be achieved using materials with lower surface energy than that of the IOLs. This can be achieved using appropriate surface chemistry and surface topography. Three designs, with enhanced hydrophobic properties, were fabricated and tested in vitro and ex vivo. All materials remove SiO within an aqueous environment. Preliminary ex vivo results were very promising, opening new possibilities for SiO removal in vitreoretinal surgeries.
研究不足
The procedure requires enlargement of the pars plana incision, and the use of ALD to modify Weck-Cel is a new technique which requires full toxicological investigation prior to human application.
1：Experimental Design and Method Selection:
Three different materials were designed and fabricated using soft lithography of polydimethylsiloxane (PDMS), three-dimensional (3D) inverse PDMS fabrication using water dissolvable particles, and atomic layer deposition (ALD) of alumina (Al2O3) on surgical cellulose fibers.
2：Sample Selection and Data Sources:
Laboratory tests included static and dynamic contact angle (CA) measurements with water and SiO, nondestructive x-ray microcomputer tomography (micro-CT), and microscopy. SiO removal was performed in vitro and ex vivo using implantable IOLs and explanted porcine eyes.
3：List of Experimental Equipment and Materials:
PDMS, ALD of Al2O3, surgical cellulose Weck-Cel, micro-CT (X-Tek HMXST225; Nikon Metrology Inc.), CCD camera (Sony XCD-V50).
4：0). Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Hydrophobicity/oleophilicity was determined by using static contact angle (CA) measurements. SiO removal from IOLs was performed in vitro and ex vivo.
5：Data Analysis Methods:
Static water CA was calculated using drop shape Laplacian analysis (Image J; National Institute of Health).
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