研究目的
Investigating the therapeutic effects of a specific herbal medicine on a particular disease.
研究成果
A CMOS image sensor with a nonlinear single-slope ADC with SOC integrated local contrast stretch for bio-microfluidic imaging system is proposed. This new method achieves the local contrast stretching by using a configurable multi-frequency counter, while retaining a simple column circuit. The captured images indicate the more important point is that the more accurate outputs of the cell light intensity region can be obtained.
研究不足
The method simplifies complexity and can be integrated into single sensor chip, but the coefficient of contrast stretch can’t change flexibly like the digital algorithm of contrast stretch.
1：Experimental Design and Method Selection:
The proposed method involves a nonlinear single-slope ADC with SOC integrated local contrast stretch using a configurable multi-frequency counter for bio-microfluidic imaging.
2：Sample Selection and Data Sources:
The method is tested with undyed carboxyl microsphere (diameter of 40μm) as the cell sample in a bio-microfluidic system.
3：List of Experimental Equipment and Materials:
A 12-bit CMOS image sensor (MT9P031) is used in the bio-microfluidic system.
4：Experimental Procedures and Operational Workflow:
The proposed ADC has three operating modes: linear mode, and two contrast stretch modes. The contrast stretch mode divides the whole light intensity range into five intervals for higher precision in the cell light intensity range.
5：Data Analysis Methods:
The method provides higher precision of cell image for the later super-resolution reconstruction.
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