研究目的
Investigating the synthesis, photophysical characterization, and application of two new thiourea derivatives as colorimetric naked-eye chemosensors for fluoride detection in solution.
研究成果
The synthesized thiourea derivatives exhibit potential as chemosensors for fluoride detection through hydrogen bonding, demonstrating significant photophysical changes upon fluoride addition. The ESIPT process plays a crucial role in the fluorescence emission properties, offering a basis for developing sensitive and selective anion sensors.
研究不足
The study focuses on fluoride detection in solution, and the sensitivity and selectivity towards other anions were not extensively explored. The interaction mechanism, while proposed, requires further validation.
1：Experimental Design and Method Selection:
The synthesis involved nucleophilic addition reaction of photoactive aminohydroxybenzazoles and p-isothiocyanate benzoic acid. Characterization was performed using HRMS-ESI, FTIR, 13C and 1H NMR spectroscopies, UV-Vis, and steady-state fluorescence.
2：Sample Selection and Data Sources:
The compounds were synthesized and purified before characterization.
3：List of Experimental Equipment and Materials:
Instruments included a Shimadzu UV-2450 spectrophotometer, Shimadzu spectrofluorometer model RF-5301PC, and a Q-TOF-MS Bruker Impact II for HRMS-ESI.
4：Experimental Procedures and Operational Workflow:
The synthesis was monitored by TLC, and products were purified by column chromatography. Photophysical measurements were conducted at 25 °C.
5：Data Analysis Methods:
UV-Vis and fluorescence data were analyzed to determine photophysical properties and anion detection capabilities.
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