研究目的
Investigating the aerobic α-oxidation of N-substituted tetrahydroisoquinolines to dihydroisoquinolones via organo-photocatalysis.
研究成果
An efficient aerobic α-oxidation of N-substituted tetrahydroisoquinolines to dihydroisoquinolones was developed using eosin Y as an organo-photocatalyst and oxygen as a green oxidant. This method provides a straightforward access to dihydroisoquinolones, important scaffolds of various bioactive compounds and other key synthetic intermediates, without requiring any metal catalysts or reagents.
研究不足
The use of stoichiometric amounts of oxidants and metal-containing catalysts or reagents is cause for both environmental and economic concerns. Additionally, limited substrate scope and operational difficulties imply the ongoing demand for a novel and efficient approach.
