研究目的
To evaluate the sensitivity and specificity of HD-OCT in the diagnosis of basal cell carcinoma by an experienced versus an inexperienced investigator and describe typical features in common differential diagnosis of BCC.
研究成果
HD-OCT can be used as an auxiliary diagnostic tool for basal cell carcinoma, even by inexperienced investigators after a short training period, with good inter-observer agreement. It provides non-invasive, real-time imaging that can help in differential diagnosis and potentially in monitoring treatment success.
研究不足
The study had a limited sample size of 43 patients and 43 lesions. Ulcerous lesions were excluded, which might limit generalizability. The inexperienced investigator received only 30 minutes of training, and further classification of non-BCC lesions was not performed by the inexperienced investigator. The study did not differentiate BCC subtypes due to limited numbers.
1：Experimental Design and Method Selection:
The study used a blinded evaluation of HD-OCT images by an experienced and inexperienced investigator, compared to histopathological diagnosis as the gold standard.
2：Sample Selection and Data Sources:
Forty-three patients with clinical suspicion of BCC were included consecutively from December 2011 to August 2012 at the Department of Dermatology and Allergology, Ludwig-Maximilian University of Munich, Germany. Patients with ulcerous lesions were excluded.
3：List of Experimental Equipment and Materials:
HD-OCT system (Skintell?, AgfaHealthCare, Belgium) with cross-sectional and horizontal imaging modes, biopsy tools for histopathology.
4：Experimental Procedures and Operational Workflow:
HD-OCT images were taken in a central position of the lesion, followed by biopsy for histopathology. Images were evaluated blinded by investigators.
5：Data Analysis Methods:
Sensitivity, specificity, positive predictive value, negative predictive value, correct rate, Youden index, and inter-rater agreement (kappa value) were calculated.
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