研究目的
To summarize recent advances in the synthesis, classification, and biomedical applications of plasmonic gold nanovesicles (GVs), including in vitro diagnosis, in vivo imaging, and in vivo therapy, and to discuss challenges and perspectives.
研究成果
Plasmonic GVs exhibit unique optical properties and a large cavity for payload delivery, making them promising for biomedical applications such as high-sensitivity diagnosis, multimodal imaging, and synergistic therapy. However, challenges remain in size optimization, stimuli-responsiveness, core diversity, functional loading, and in vivo evaluation for clinical translation.
研究不足
The paper discusses challenges and perspectives, including the need for size control (50-150 nm for optimal tumor accumulation and clearance), development of more stimuli-responsive polymers, exploration of diverse GNP morphologies as cores, loading of functional substances for multimodal imaging and therapy, and more in vivo assessments (e.g., toxicity, pharmacokinetics).
1：Experimental Design and Method Selection:
This review paper does not describe a specific experimental design or methodology as it is a review article summarizing existing research. It discusses synthesis methods (self-assembly and in situ growth), classification based on GNP cores, and applications in diagnosis, imaging, and therapy.
2：Sample Selection and Data Sources:
The paper reviews various studies and examples from the literature, citing references for different types of GVs and their applications.
3：List of Experimental Equipment and Materials:
Not applicable as this is a review; specific equipment and materials are mentioned in cited studies but not detailed here.
4：Experimental Procedures and Operational Workflow:
Not applicable; the paper describes general procedures from literature, such as film rehydration, selective solvents, and microfluidic methods for synthesis.
5：Data Analysis Methods:
Not applicable; the paper summarizes results from other studies without detailing analysis methods.
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