研究目的
To evaluate the functional results after implantation of the Argus II retinal prosthesis system in a deaf-blind patient with retinitis pigmentosa and Usher syndrome, including proposing a new method for assessing phosphene characteristics and their correlations with physiological parameters.
研究成果
The implantation of the Argus II system in a deaf-blind patient with Usher syndrome was successful, with improvements in visual function and social adaptation. No significant correlations were found between phosphene size and physiological parameters except a weak positive correlation with perceptual threshold. The study highlights the potential of retinal prostheses for rehabilitation in deaf-blind individuals but underscores the need for further research with larger samples to understand phosphene formation and optimize technology.
研究不足
The study is based on a single clinical case, limiting statistical power and generalizability. The patient's deaf-blindness and reliance on subjective phosphene drawings may introduce variability. Technical limitations include the heterogeneity of the retinal environment and potential inaccuracies in measurements.
1：Experimental Design and Method Selection:
The study involved a clinical case of the first retinal implant surgery in Russia using the Argus II system. Methods included clinical examinations, phosphene evaluation through patient drawings, and statistical correlation analysis using Spearman rank correlation.
2：Sample Selection and Data Sources:
One 59-year-old male patient with Usher syndrome was selected from a database of deaf-blind individuals. Data included pre- and post-surgery clinical measurements and patient-drawn phosphenes.
3：List of Experimental Equipment and Materials:
Equipment included slit lamp biomicroscopy, visual acuity tests, SD-OCT (RTVue xR Avanti, Optovue, USA), fundus photography (VISUCAM 500, Zeiss Meditec AG, Germany), pneumotonometry (HNT-7000, Huvitz, Rep. of Korea), perimetry (Octopus 900, Haag-Streit, Switzerland), axial length measurement (Lenstar 900, Haag-Streit, Switzerland), ultrasound b-scan (B-scan plus, Accutome, USA), and custom software for perceptual threshold measurement. Materials included the Argus II retinal prosthesis system (Second Sight, USA).
4：Experimental Procedures and Operational Workflow:
Pre- and post-surgery clinical exams were conducted. After surgery, phosphenes were elicited by electrode stimulation, drawn by the patient, digitalized in Adobe Photoshop, and analyzed. Rehabilitation sessions included microscanning, macroscanning, and outdoor activities.
5：Data Analysis Methods:
Statistical analysis was performed using R software for Spearman rank correlation to assess relationships between phosphene size, subimplant interface height, retinal thickness, impedance, and perceptual threshold.
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